Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0144Conserved hypothetical protein. (409 aa)    
Predicted Functional Partners:
rgg
Positive transcriptional regulator of glucosyltransferase and Spp phenotype.
 
   
 0.698
spr1605
Hypothetical protein.
  
     0.671
spr0702
Conserved hypothetical protein.
  
    0.670
plcR
Transcriptional activator.
      
 0.597
mutR
Positive transcriptional regulator of mutA.
 
   
 0.596
plcR-2
Transcriptional activator.
      
 0.596
spr0143
Hypothetical protein.
  
    0.579
spr0142
Hypothetical protein.
  
    0.564
spr1117
Conserved hypothetical protein; Probable acetyltransferase.
  
    0.542
rggD
Transcriptional regulator.
  
     0.531
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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