Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
ABC-SBP-4ABC transporter solute-binding protein - unknown substrate; Belongs to the nlpA lipoprotein family. (284 aa)    
Predicted Functional Partners:
ABC-MSD
ABC transporter membrane-spanning permease - unknown substrate.
 0.999
ABC-NBD-2
ABC transporter ATP-binding protein - unknown substrate; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
 
 0.996
ABC-SBP-3
ABC transporter substrate-binding protein - amino acid transport.
  
  
 0.690
dapE
Succinyl-diaminopimelic descuccinlyase (ArgE/DapE/Acy1 family protein).
     
 0.690
spr1095
O-acetylhomoserine sulfhydrylase, truncation.
  
    0.521
spr1096
O-acetylhomoserine sulfhydrylase, truncation.
  
    0.521
metK
S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
  
 0.456
metF
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
  
 0.415
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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