Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
hk07Histidine kinase. (231 aa)    
Predicted Functional Partners:
rr07
Response regulator.
 
 
 0.999
spr0152
Conserved hypothetical protein.
 
  
 0.968
hk09
Histidine kinase.
  
  
 
0.923
ABC-SBP
ABC transporter solute binding protein - sugar transport.
 
   
 0.762
spr0155
Hypothetical protein.
       0.758
spr0156
Conserved hypothetical protein; Similar to NrdI protein.
       0.752
rr09
Response regulator.
 
  
 0.715
spr1951
Conserved hypothetical protein; Probable sugar hydrolase.
 
   
 0.671
ABC-MSP
ABC transporter membrane-spanning permease - sugar transport.
 
   
 0.662
spr1953
Conserved hypothetical protein; Similar to a sugar hydrolase in Lactococcus lactis subsp. lactis.
 
   
 0.658
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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