Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0225Hypothetical protein. (65 aa)    
Predicted Functional Partners:
spr1951
Conserved hypothetical protein; Probable sugar hydrolase.
 
    0.871
spr0798
Hypothetical protein.
   
    0.768
spr0224
ABC transporter substrate-binding protein - iron transport, truncation.
 
    0.728
celA
Competence induced; comE-like protein A also known as CilE; Putative DNA uptake by homology.
  
    0.697
spr0311
Hypothetical protein.
   
    0.692
clpE
ATP dependent protease; Belongs to the ClpA/ClpB family.
   
    0.692
cmk
Cytidylate kinase.
   
    0.692
scrR-2
Sucrose operon repressor (SCR operon regulatory protein).
   
    0.692
spr0223
ABC transporter solute-binding protein - iron transport, truncation.
 
     0.683
spr0073
Hypothetical protein.
   
    0.668
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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