Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
manMPhosphotransferase system, mannose-specific EIIC. (267 aa)    
Predicted Functional Partners:
manN
Phosphotransferase system, mannose-specific EIID.
 0.999
manL
Phosphotransferase system, mannose-specific EIIAB.
 
 0.999
PTS-EII-19
Phosphotransferase system sugar-specific EII component.
 0.995
PTS-EIID
Phosphotransferase system sugar-specific EIID component.
 0.989
PTS-EII-22
Phosphotransferase system sugar-specific EII component.
 
 0.985
PTS-EII
Phosphotransferase system sugar-specific EII component.
 
 0.979
pmi
Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.
 
  
  0.936
PTS-EII-20
Phosphotransferase system sugar-specific EII component.
  
  
 
0.921
spr0373
Conserved hypothetical protein.
 
   
 0.915
ptsH
Histidine-containing phosphocarrier protein of the PTS.
  
 
 0.909
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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