node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dfr | folC | spr1429 | spr0178 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.913 |
dfr | pbp2b | spr1429 | spr1517 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Penicillin-binding protein 2B. | 0.654 |
dfr | pbpX | spr1429 | spr0304 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. | 0.649 |
dfr | sulA | spr1429 | spr0266 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.963 |
dfr | sulB | spr1429 | spr0267 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.949 |
dfr | sulD | spr1429 | spr0269 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aldolase-pyrophosphokinase; Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin diphosphate. In the N-terminal section; belongs to the DHNA family. | 0.609 |
folC | dfr | spr0178 | spr1429 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.913 |
folC | pabB | spr0178 | spr0582 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Para-aminobenzoate synthetase. | 0.428 |
folC | sulA | spr0178 | spr0266 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.992 |
folC | sulB | spr0178 | spr0267 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.926 |
folC | sulC | spr0178 | spr0268 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase. | 0.965 |
folC | sulD | spr0178 | spr0269 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Aldolase-pyrophosphokinase; Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin diphosphate. In the N-terminal section; belongs to the DHNA family. | 0.969 |
imdH | pabB | spr2033 | spr0582 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Para-aminobenzoate synthetase. | 0.443 |
imdH | sulA | spr2033 | spr0266 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.638 |
imdH | sulC | spr2033 | spr0268 | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | GTP cyclohydrolase. | 0.441 |
pabB | folC | spr0582 | spr0178 | Para-aminobenzoate synthetase. | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.428 |
pabB | imdH | spr0582 | spr2033 | Para-aminobenzoate synthetase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.443 |
pabB | sulA | spr0582 | spr0266 | Para-aminobenzoate synthetase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.976 |
pabB | sulB | spr0582 | spr0267 | Para-aminobenzoate synthetase. | Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.428 |
pabB | sulC | spr0582 | spr0268 | Para-aminobenzoate synthetase. | GTP cyclohydrolase. | 0.572 |