STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sulCGTP cyclohydrolase. (184 aa)    
Predicted Functional Partners:
sulD
Aldolase-pyrophosphokinase; Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin diphosphate. In the N-terminal section; belongs to the DHNA family.
  
 0.999
sulA
Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives.
  
 0.995
ribA
Riboflavin biosynthesis; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
 
 0.990
sulB
Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family.
  
  
 0.979
folC
Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family.
  
  
 0.965
ribD
Riboflavin biosynthese; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.871
ndk
Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 0.841
pykF
Pyruvate kinase I; fructose-stimulated.
  
 
  0.816
relA
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
 0.806
nrdD
Ribonucleotide reductase, class III, anaerobic.
   
 
  0.804
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.