node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
folC | pabB | spr0178 | spr0582 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Para-aminobenzoate synthetase. | 0.428 |
folC | ribD | spr0178 | spr0164 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Riboflavin biosynthese; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.842 |
folC | sulA | spr0178 | spr0266 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.992 |
folC | sulB | spr0178 | spr0267 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.926 |
folC | sulC | spr0178 | spr0268 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | GTP cyclohydrolase. | 0.965 |
folC | sulD | spr0178 | spr0269 | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | Aldolase-pyrophosphokinase; Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin diphosphate. In the N-terminal section; belongs to the DHNA family. | 0.969 |
ftsH | pabB | spr0012 | spr0582 | Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Para-aminobenzoate synthetase. | 0.420 |
ftsH | sulA | spr0012 | spr0266 | Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.444 |
ftsH | sulC | spr0012 | spr0268 | Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | GTP cyclohydrolase. | 0.589 |
ftsH | sulD | spr0012 | spr0269 | Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | Aldolase-pyrophosphokinase; Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin diphosphate. In the N-terminal section; belongs to the DHNA family. | 0.688 |
pabB | folC | spr0582 | spr0178 | Para-aminobenzoate synthetase. | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.428 |
pabB | ftsH | spr0582 | spr0012 | Para-aminobenzoate synthetase. | Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.420 |
pabB | ribD | spr0582 | spr0164 | Para-aminobenzoate synthetase. | Riboflavin biosynthese; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.587 |
pabB | sulA | spr0582 | spr0266 | Para-aminobenzoate synthetase. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate, the immediate precursor of folate derivatives. | 0.976 |
pabB | sulB | spr0582 | spr0267 | Para-aminobenzoate synthetase. | Dihydrofolate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.428 |
pabB | sulC | spr0582 | spr0268 | Para-aminobenzoate synthetase. | GTP cyclohydrolase. | 0.572 |
pabB | sulD | spr0582 | spr0269 | Para-aminobenzoate synthetase. | Aldolase-pyrophosphokinase; Catalyzes two sequential steps of tetrahydrofolate biosynthesis, the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin diphosphate. In the N-terminal section; belongs to the DHNA family. | 0.856 |
pabB | trpE | spr0582 | spr1637 | Para-aminobenzoate synthetase. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.877 |
pabB | trpG | spr0582 | spr1636 | Para-aminobenzoate synthetase. | Anthranilate synthase component II (glutamine amido-transferase). | 0.999 |
ribD | folC | spr0164 | spr0178 | Riboflavin biosynthese; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | Dihydrofolate:folylpolyglutamate synthetase; Belongs to the folylpolyglutamate synthase family. | 0.842 |