Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
PTS-EII-6Phosphotransferase system sugar-specific EII component. (163 aa)    
Predicted Functional Partners:
PTS-EII-7
Phosphotransferase system sugar-specific EII component.
 
 0.998
PTS-EII-8
Phosphotransferase system sugar-specific EII component.
 
 0.998
PTS-EII-5
Phosphotransferase system sugar-specific EII component.
 
 
 0.996
ptsH
Histidine-containing phosphocarrier protein of the PTS.
   
 0.931
PTS-EII-19
Phosphotransferase system sugar-specific EII component.
 
 
 0.906
PTS-EII-20
Phosphotransferase system sugar-specific EII component.
 
 
 0.906
spr0297
Hypothetical protein.
 
     0.905
ugl
Unsaturated glucuronyl hydrolase; Catalyzes the hydrolysis of unsaturated hyaluronate and chondroitin disaccharides. Also degrades unsaturated heparin disaccharides. Releases 4-deoxy-4,5-didehydro D-glucuronic acid or 4- deoxy-4,5-didehydro L-iduronic acid from chondroitin disaccharides, hyaluronan disaccharides and heparin disaccharides and cleaves both glycosidic (1->3) and (1->4) bonds. Prefers sulfated glycosaminoglycans compared to unsulfated glycosaminoglycans. Probably required for mammalian cells invasion through the degradation of extracellular sulfated glycosaminoglycans such [...]
 
   
 0.904
PTS-EIID
Phosphotransferase system sugar-specific EIID component.
 
 
 0.894
manN
Phosphotransferase system, mannose-specific EIID.
 
 
 0.853
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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