STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pbpXPenicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. (750 aa)    
Predicted Functional Partners:
pbpA
Penicillin-binding protein 1A; Cell wall formation; In the C-terminal section; belongs to the transpeptidase family.
 
 0.999
pbp2a
Penicillin-binding protein 2a.
 
 
 0.998
pbp1b
Penicillin-binding protein 1b.
 
 0.998
ftsW
Cell division protein FtsW; Belongs to the SEDS family.
 
 0.997
divIB
Cell division protein DivIB; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
 
 
 0.980
mraY
Undecaprenyl-phosphate-UDP-MurNAc-pentapeptide phospho-MurNAc-pentapeptide transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
 
  
 0.973
ftsL
Cell division protein; Essential cell division protein; Belongs to the FtsL family.
  
 
 0.972
rodA
Rod shape determining protein; Belongs to the SEDS family.
 
 0.971
pbp2b
Penicillin-binding protein 2B.
  
  
0.959
yllC
YllC protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA.
 
  
 0.956
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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