Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
spr0328Conserved hypothetical protein; Involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc- alpha) from extracellular host glycoproteins. Representative of a broadly important class of virulence factors. (1767 aa)    
Predicted Functional Partners:
nanA
Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.
 
  
0.748
cglA
Competence induced; comG-like protein A; Also known as cilD.
  
 
 0.645
cglB
Competence induced; comG-like protein B.
  
  
 0.629
cglC
Competence induced; comG-like protein C.
  
  
 0.621
prtA
Cell wall-associated serine proteinase precursor PrtA.
   
  
 0.610
spr1859
Conserved hypothetical protein; Competence induced; related to comYD.
  
  
 0.601
zmpB
Zinc metalloprotease; Similar to IgA1 protease.
  
   
 0.592
celB
Competence induced; comE-like protein B; Putative DNA uptake by homology.
  
  
 0.592
nanB
Sialidase B precursor (neuraminidase B).
  
  
 0.564
comFA
Involved in transformation; required for DNA uptake but not for binding; Related to ATP-dependent RNA/DNA helicases.
   
  
 0.558
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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