Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mtlDMannitol-1-phosphate 5-dehydrogenase. (378 aa)    
Predicted Functional Partners:
mtlA
Mannitol PTS EII; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport.
 
 
 0.999
mtlF
Mannitol-specific enzyme IIA component.
 
 0.999
spr0357
Conserved hypothetical protein; Putative transcriptional regulator.
 
  
 0.972
pfkA
6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
 
 0.917
pmi
Mannose-6-phosphate isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.
  
 
 0.911
scrK
Fructokinase.
   
 
 0.903
bglG
Transcription antiterminator BglG family.
 
  
 0.775
phnA
Required for expression of the phosphonate utilization phenotype in E. coli.
     
 0.724
fruA
Fructose specific-phosphotransferase system IIBC component.
  
  
 0.691
spr1940
Conserved hypothetical protein; Probable transcriptional antiterminator, bglG family.
 
  
 0.638
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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