Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
licTTranscriptional antiterminator (BglG family). (279 aa)    
Predicted Functional Partners:
PTS-EII-12
Phosphotransferase system sugar-specific EII component.
 
 0.982
scrA
Phosphotransferase system enzyme II.
 
 
 0.829
bglH
6-phospho-beta-glucosidase; Belongs to the glycosyl hydrolase 1 family.
 
  
 0.824
treP
Phosphotransferase system, trehalose-specific IIBC component.
 
 
 0.806
PTS-EII-15
Phosphotransferase system sugar-specific EII component.
 
 
 0.725
ptsG
PTS glucose-specific enzyme IIABC component.
 
 
 0.690
bglG
Transcription antiterminator BglG family.
 
  
 0.666
msmF
ABC transporter membrane-spanning permease - multiple sugars.
      
 0.625
hprK
HPr(ser-P)kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable ca [...]
      
 0.562
ptsI
PTS enzyme I; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
   
 
 0.501
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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