Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0553Hypothetical protein. (167 aa)    
Predicted Functional Partners:
spr0552
Conserved hypothetical protein.
  
    0.850
spr0554
Conserved hypothetical protein; Putative carboxypeptidase.
  
    0.802
glnA
Glutamine synthetase type 1.
  
   0.552
spr1932
Conserved hypothetical protein; Putative permease.
  
   
 0.472
rgg
Positive transcriptional regulator of glucosyltransferase and Spp phenotype.
  
     0.466
rplK
50S Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
  
    0.444
brnQ
Branched-chain amino acid transport system carrier protein; Component of the transport system for branched-chain amino acids.
       0.442
spr0440
Hypothetical protein; Similar to endo-beta-N-acetylglucosaminidase.
  
    0.430
ksgA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
   
 
 0.411
rggD
Transcriptional regulator.
  
    0.410
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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