Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0595Conserved hypothetical protein. (126 aa)    
Predicted Functional Partners:
spr0594
Conserved hypothetical protein.
 
     0.869
spr0596
Hypothetical protein.
  
  
 0.664
cpsY
Regulatory function on capsule expression; Belongs to the LysR transcriptional regulatory family.
  
  
 0.596
sodA
Manganese co-factored superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. May play a critical role against oxidative stress, affecting both the survival and the virulence of S.pneumoniae (By similarity). Belongs to the iron/manganese superoxide dismutase family.
   
 
 0.560
spr1855
Conserved hypothetical protein.
  
    0.560
ybeY
Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA.
   
   0.530
divIB
Cell division protein DivIB; Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.
 
     0.525
rpsQ
30S Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.
   
   0.511
spr0966
Conserved hypothetical protein; Probable acid-CoA ligase.
   
 
 0.511
rplQ
50S Ribosomal protein L17.
  
   0.490
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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