node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
carB | pyrB | spr1153 | spr1155 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
carB | pyrC | spr1153 | spr1053 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.996 |
carB | pyrD | spr1153 | spr0866 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.843 |
carB | pyrE | spr1153 | spr0614 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.960 |
carB | pyrF | spr1153 | spr0613 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Orotidine-5'-decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.924 |
carB | pyrR | spr1153 | spr1156 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Transcriptional attenuation of the pyrimidine operon / uracil phosphoribosyltransferase activity; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.976 |
carB | spr0186 | spr1153 | spr0186 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Hypothetical protein. | 0.429 |
carB | upp | spr1153 | spr0655 | Carbamoylphosphate synthase (ammonia), heavy subunit. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.594 |
pyrB | carB | spr1155 | spr1153 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Carbamoylphosphate synthase (ammonia), heavy subunit. | 0.999 |
pyrB | pyrC | spr1155 | spr1053 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | 0.999 |
pyrB | pyrD | spr1155 | spr0866 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.922 |
pyrB | pyrE | spr1155 | spr0614 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.979 |
pyrB | pyrF | spr1155 | spr0613 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Orotidine-5'-decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.983 |
pyrB | pyrH | spr1155 | spr0845 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | UMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.574 |
pyrB | pyrR | spr1155 | spr1156 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Transcriptional attenuation of the pyrimidine operon / uracil phosphoribosyltransferase activity; Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. | 0.998 |
pyrB | upp | spr1155 | spr0655 | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.625 |
pyrC | carB | spr1053 | spr1153 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Carbamoylphosphate synthase (ammonia), heavy subunit. | 0.996 |
pyrC | pyrB | spr1053 | spr1155 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Aspartate carbamoyltransferase; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
pyrC | pyrD | spr1053 | spr0866 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily. | 0.991 |
pyrC | pyrE | spr1053 | spr0614 | Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.950 |