Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
spr0633Conserved hypothetical protein. (216 aa)    
Predicted Functional Partners:
ABC-NBD-9
ABC transporter ATP-binding protein - cobalt or other cation transport.
 
 
 0.985
spr0631
Conserved hypothetical protein.
 
  
 0.980
ABC-NBP
ABC transporter ATP-binding protein - unknown substrate; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
  
 0.938
stpA
ABC transporter ATP-binding protein - unknown substrate; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
  
 0.938
bioY
Biotin synthase.
  
 0.924
ABC-MSD-2
ABC transporter membrane-spanning permease - unknown substrate.
  
  
  0.915
spr1292
Conserved hypothetical protein.
     
  0.900
ABC-MSP-22
ABC transporter membrane-spanning permease - unknown substrate; Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates.
     
  0.900
tenA
Transcriptional regulator of extracellular enzyme genes; Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway; Belongs to the TenA family.
 
  
 0.848
spr1112
Conserved hypothetical protein; Probable membrane protein.
   
 
 0.848
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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