Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0675Hypothetical protein. (176 aa)    
Predicted Functional Partners:
rlmN
Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family.
       0.805
spr0677
Hypothetical protein.
       0.805
ABC-NBD-10
ABC transporter ATP-binding protein - unknown substrate.
       0.804
spr0177
Conserved hypothetical protein; Belongs to the UPF0473 family.
  
     0.707
rpoE
RNA polymerase (delta subunit); Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; Belongs to the RpoE family.
  
     0.686
ABC-MSP-6
ABC transporter membrane-spanning permease - unknown substrate.
  
     0.674
dnaI
Primosome component (helicase loader).
  
     0.672
spr0837
Conserved hypothetical protein; Involved in initiation control of chromosome replication. Belongs to the YabA family.
  
     0.669
nagD
N-acetyl-glucosamine matabolism.
 
  
 0.664
spr1594
Conserved hypothetical protein; Similar to GTP-binding protein.
  
   
 0.640
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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