STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ciaHSensor protein CiaH histide kinase; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility. Probably phosphorylates CiaR. (444 aa)    
Predicted Functional Partners:
ciaR
Response regulator, transcriptional regulatory protein; Member of the two-component regulatory system CiaH/CiaR. Involved in early steps of competence regulation and in penicillin susceptibility.
 0.999
acoL
Dihydrolipoamide dehydrogenase.
    
 0.971
sphtra
Serine protease.
 
  
 0.907
rr08
Response regulator.
 
 
 0.881
vncR
VncR, response regulator.
 
 
 0.875
rr02
Response regulator.
 
 
 0.874
phoP
Response regulator.
 
 
 0.872
rr06
Response regulator.
 
 
 0.828
cpoA
Glycosyltransferase; Galactosyltransferase involved in the biosynthesis of the bilayer-forming membrane lipid alpha-galactosyl-glucosyldiacylglycerol which is involved in maintaining constant nonbilayer/bilayer conditions (curvature packing stress). Also involved in the beta-lactam resistance. Catalyzes the transfer of a galactosyl residue from UDP-Gal to alpha-glucosyl-DAG (1,2-diacyl-3-O-(alpha-D-glucopyranosyl)-sn- glycerol) acceptor to form the corresponding galactosyl-glycosyl-DAG product (3-O-alpha-(D-galactopyranosyl-alpha-(1->2)-D-glucopyranosyl)- 1,2-diacyl-sn-glycerol). It ca [...]
   
  
 0.819
csrR
Response regulator.
 
 
 0.815
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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