Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dacAD-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. (413 aa)    
Predicted Functional Partners:
pbp2b
Penicillin-binding protein 2B.
  
 
 0.958
pbpX
Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
  
 
 0.957
pbp1b
Penicillin-binding protein 1b.
  
 
 0.952
pbpA
Penicillin-binding protein 1A; Cell wall formation; In the C-terminal section; belongs to the transpeptidase family.
  
 
 0.950
pbp2a
Penicillin-binding protein 2a.
  
 
 0.949
spr0554
Conserved hypothetical protein; Putative carboxypeptidase.
    
 0.912
spr0777
Conserved hypothetical protein; Putative permease.
       0.633
rlmH
Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family.
  
  
 0.544
pepA
Glutamyl aminopeptidase.
   
  
 0.499
ropA
Trigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily.
  
    0.435
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.