Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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textmining
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experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fruBFructose-1-phosphate kinase; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (303 aa)    
Predicted Functional Partners:
fruA
Fructose specific-phosphotransferase system IIBC component.
 
 
 0.999
fruR
Transcriptional repressor of the fructose operon.
 
  
 0.986
fba
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.
 
 
 0.952
pfkA
6-phosphofructokinase I; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
     
 0.932
galM
Aldose-1-epimerase (mutarotase); Converts alpha-aldose to the beta-anomer.
  
  
 0.797
scrA
Phosphotransferase system enzyme II.
  
  
 0.768
nagB
N-acetylglucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
     
 0.766
mtlF
Mannitol-specific enzyme IIA component.
 
  
 0.750
deoR
DEOR-type transcriptional regulator.
 
  
 0.747
lacR
Lactose phosphotransferase system repressor.
 
  
 0.741
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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