Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0785Hypothetical protein. (282 aa)    
Predicted Functional Partners:
spr0786
Hypothetical protein.
 
     0.935
spr0789
Hypothetical protein.
 
     0.850
spr0788
Hypothetical protein.
 
     0.791
spr0669
Hypothetical protein.
  
    0.609
iga
Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region.
  
     0.592
thiI
Thiamin biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.
       0.578
zmpB
Zinc metalloprotease; Similar to IgA1 protease.
  
     0.573
spr0783
Probable pyridoxal-phosphate dependent aminotransferase.
       0.572
xylS
Alpha-xylosidase; Belongs to the glycosyl hydrolase 31 family.
      0.569
nikS
Nikkomycin biosynthesis protein, carboxylase.
 
     0.501
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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