Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr0895Conserved hypothetical protein. (163 aa)    
Predicted Functional Partners:
thmA
Amphipathic pore-forming peptide precursor.
      
 0.881
spr0890
Hypothetical protein.
 
     0.849
dnaQ
DNA polymerase III, epsilon chain.
 
     0.761
dnaB
Chromosome replication initiation protein/membrane attachment protein, Putative.
  
     0.746
adcR
Transcriptional repressor for Zn(2+)-responsive expression.
  
     0.732
spr0897
Hypothetical protein.
       0.730
spr0008
Hypothetical protein.
  
     0.718
spr1416
Hypothetical protein.
  
     0.683
atpE
Proton-translocating ATPase, F0 sector, subunit c; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
  
     0.681
spr0009
Conserved hypothetical protein.
  
     0.666
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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