Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
phtDPneumococcal histidine triad protein D precursor. (853 aa)    
Predicted Functional Partners:
spr0909
Hypothetical protein.
   
    0.999
adcA
ABC transporter substrate-binding protein - Zinc (Zn2+) transport; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.999
adcB
ABC transporter membrane-spanning permease - Zinc (Zn2+) transport.
   
  
 0.999
adcC
ABC transporter ATP-binding domain - Zinc (Zn2+) permease; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity).
   
  
 0.999
adcR
Transcriptional repressor for Zn(2+)-responsive expression.
   
  
 0.999
lmb
Lipoprotein; Belongs to the bacterial solute-binding protein 9 family.
  
  
 0.994
pspC
Choline binding protein A.
  
 
 0.943
ply
Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
   
  
 0.930
pcpA
Choline-binding protein.
      
 0.930
pspA
Surface protein pspA precursor.
  
 
 0.905
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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