Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
nplTNeopullulanase; Belongs to the glycosyl hydrolase 13 family. (587 aa)    
Predicted Functional Partners:
malM
4-alpha-glucanotransferase (amylomaltase); Belongs to the disproportionating enzyme family.
 
 
 0.987
pulI
Thermostable pullulanase; Belongs to the glycosyl hydrolase 13 family.
 
 0.983
glgB
1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.
 
 
 0.970
malP
Maltodextrin phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.
  
 0.962
spr0669
Hypothetical protein.
  
 
  0.906
amy
Alpha-amylase precursor; Belongs to the glycosyl hydrolase 13 family.
  
 
0.906
cglC
Competence induced; comG-like protein C.
      
 0.882
malX
ABC transporter substrate-binding protein - maltose/maltodextrin; Binding protein for maltose and maltodextrin; involved in its cellular uptake.
 
  
 0.854
pulA
Alkaline amylopullulanase.
  
0.833
malD
ABC transporter membrane-spanning permease - maltose/maltodextrin; Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane.
 
  
 0.792
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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