Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
mefEABC transporter membrane-spanning permease - macrolide efflux. (403 aa)    
Predicted Functional Partners:
spr1932
Conserved hypothetical protein; Putative permease.
      
 0.882
mutR-2
Similar to positive transcriptional regulator MutR.
 
     0.754
msrA
Peptide methionine sulfoxide reductase paralog; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity).
     
 0.731
spr1509
Conserved hypothetical protein; Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis; Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.
  
   
 0.660
msrA-2
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation (By similarity). Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
     
 0.653
spr0895
Conserved hypothetical protein.
  
     0.616
pbpA
Penicillin-binding protein 1A; Cell wall formation; In the C-terminal section; belongs to the transpeptidase family.
   
  
 0.614
pbpX
Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.
   
  
 0.607
pbp2b
Penicillin-binding protein 2B.
   
  
 0.607
ABC-N/P
ABC transporter ATP-binding/membrane-spanning protein - unknown substrate.
      
 0.552
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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