Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr1102Uncharacterized restriction enzyme, interrupted-N. (625 aa)    
Predicted Functional Partners:
spr1101
Uncharacterized restriction enzyme, interrupted-C.
     0.986
spnIM
DNA modification methyltransferase; Belongs to the N(4)/N(6)-methyltransferase family.
     
 0.929
spr1103
Hypothetical protein.
       0.590
hsdM
EcoE type I restriction modification enzyme M subunit.
  
 
 0.579
spr1104
Hypothetical protein.
       0.578
vicX
VicX protein.
       0.512
hk02
Histidine kinase.
       0.512
rr02
Response regulator.
       0.512
mutY
Similar to A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs.
       0.512
hsdM-2
Type I restriction modification enzyme methylase subunit.
  
 
 0.495
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.