Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ABC-NDBABC transporter ATP-binding protein - unknown substrate. (252 aa)    
Predicted Functional Partners:
spr1201
Hypothetical protein.
  
 
 0.892
spr0695
Conserved hypothetical protein.
 
 0.888
ABC-NP-2
ABC transporter ATP-binding/membrane spanning protein - multidrug resistance.
 
    
0.798
ptrB
Protease II (oligopeptidase B).
       0.776
spr1496
Hypothetical protein.
  
 
 0.773
ABC-NBD-20
ABC transporter ATP-binding protein - multidrug efflux.
  
     0.729
spr1826
Conserved hypothetical protein.
 
 
 0.683
spr1205
Conserved hypothetical protein.
  
  
 0.681
gcp
Secreted metalloendopeptidase Gcp; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family.
 
    0.573
vex1
ABC transporter membrane-spanning permease - Pep export.
  
 
 0.446
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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