STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgdAPeptidoglycan GlcNAc deacetylase; Catalyzes the deacetylation of N-acetylglucosamine (GlcNAc) residues in peptidoglycan, a modification that confers host lysozyme resistance and contributes to pneumococcal virulence. (463 aa)    
Predicted Functional Partners:
spr0091
Conserved hypothetical protein; Putative sugar transferase related protein.
 
  
 0.784
strH
Beta-N-acetyl-hexosaminidase precursor.
 
  
 0.626
spr1332
Conserved hypothetical protein; Putative oxidoreductase.
  
    0.533
cspR
rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
     
 0.518
lytD
Teichoic acid phosphorylcholine esterase/choline binding protein E (cbpE).
 
  
 0.505
bgaA
Beta-galactosidase precursor.
  
  
 0.470
srtA
Sortase; Putative, proposed to perform the peptide cleavage and the transpeptidation during the process of anchoring proteins to Gram-positive bacterial cell walls.
  
  
 0.464
cinA
Competence induced protein A; Belongs to the CinA family.
     
 0.464
pkn2
Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...]
 
  
 0.461
lytA
Autolysin (N-acetylmuramoyl-L-alanine amidase).
  
  
 0.444
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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