STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ssbASingle stranded binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (156 aa)    
Predicted Functional Partners:
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.969
recO
Conserved hypothetical protein; Involved in DNA repair and RecF pathway recombination (By similarity). Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation ; Belongs to the RecO family.
   
 
 0.964
smf
DNA processing Smf protein; Protein that helps load RecA onto ssDNA during transformation. Required for DNA transformation. Not required for DNA uptake but for a later stage of transformation. Thought to interact at the cell pole with newly imported transforming ssDNA which it binds cooperatively, protecting linear and circular ssDNA from nuclease action. Forms bridges between DNA segments. Favors the loading of RecA onto ssDNA and formation of RecA-DNA filaments, triggering RecA- catalysis of ATP-driven homologous DNA pairing. Belongs to the DprA/Smf family.
 
  
 0.958
rpsF
30S Ribosomal protein S6 (S6); Binds together with S18 to 16S ribosomal RNA.
  
  
 0.944
ssbB
Single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism.
  
  
0.917
recA
DNA recombination/repair; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs (By similarity). It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). Required for DNA transformation; protects transforming DNA from degradation, possibly in combination with DprA. Present at 15,000-30,000 monomers per competent cell.
 
 
 
 0.897
recF
Recombination protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). Plays no role in chromosomal or plasmid transformation but is required for resolution of chromosome dimers occurring as intermediates in the formation of merodiploids by transformation.
     
 0.872
rpsR
30S Ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family.
 
  
 0.871
dnaX
DNA-directed DNA polymerase III chain; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
   
 
 0.864
dnaE
DNA-polymerase III alpha-chain.
 
 
 
 0.838
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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