STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spr1403Hypothetical protein. (2551 aa)    
Predicted Functional Partners:
spr0440
Hypothetical protein; Similar to endo-beta-N-acetylglucosaminidase.
      
 0.908
spr0466
Conserved hypothetical protein, truncation; blpB.
  
  
 0.861
spr0400
Conserved hypothetical protein.
      
 0.841
spr1730
Hypothetical protein.
      
 0.727
spr0075
Conserved hypothetical protein; Similar to cell wall-associated serine proteinase.
     
 0.726
spr1404
Conserved hypothetical protein; Putative Mga-like regulatory protein.
  
    0.703
pfbA
Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.
  
 
 0.680
pspC
Choline binding protein A.
  
 
 0.666
spr1183
ABC transporter ATP-bindng protein - possibly multidrug efflux, truncation.
 
  
 0.659
ftsK
Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region (By similarity). Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination; Belongs to the FtsK/SpoIIIE/SftA family.
   
 
 0.649
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.