node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cobQ | fecE | spr1444 | spr1686 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | ABC transporter ATP-binding protein - ferric iron transport. | 0.517 |
cobQ | glnA | spr1444 | spr0444 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Glutamine synthetase type 1. | 0.663 |
cobQ | merA | spr1444 | spr1442 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Oxidoreductase (Mercury (II) reductase). | 0.572 |
cobQ | murC | spr1444 | spr1373 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | 0.722 |
cobQ | murE | spr1444 | spr1384 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L- lysine Ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. | 0.757 |
cobQ | murG | spr1444 | spr0604 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.958 |
cobQ | murM | spr1444 | spr0540 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Serine/alanine adding enzyme. | 0.944 |
cobQ | murT | spr1444 | spr1443 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Conserved hypothetical protein; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. Belongs to the MurCDEF family. MurT subfamily. | 0.999 |
cobQ | pepQ | spr1444 | spr1445 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Dipeptidase; Belongs to the peptidase M24B family. | 0.525 |
cobQ | trpG | spr1444 | spr1636 | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | Anthranilate synthase component II (glutamine amido-transferase). | 0.593 |
fecE | cobQ | spr1686 | spr1444 | ABC transporter ATP-binding protein - ferric iron transport. | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | 0.517 |
fecE | murT | spr1686 | spr1443 | ABC transporter ATP-binding protein - ferric iron transport. | Conserved hypothetical protein; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. Belongs to the MurCDEF family. MurT subfamily. | 0.429 |
glnA | cobQ | spr0444 | spr1444 | Glutamine synthetase type 1. | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | 0.663 |
glnA | murT | spr0444 | spr1443 | Glutamine synthetase type 1. | Conserved hypothetical protein; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. Belongs to the MurCDEF family. MurT subfamily. | 0.592 |
merA | cobQ | spr1442 | spr1444 | Oxidoreductase (Mercury (II) reductase). | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | 0.572 |
merA | murT | spr1442 | spr1443 | Oxidoreductase (Mercury (II) reductase). | Conserved hypothetical protein; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. Belongs to the MurCDEF family. MurT subfamily. | 0.572 |
merA | pepQ | spr1442 | spr1445 | Oxidoreductase (Mercury (II) reductase). | Dipeptidase; Belongs to the peptidase M24B family. | 0.438 |
murC | cobQ | spr1373 | spr1444 | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Cobyric acid synthase; The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. | 0.722 |
murC | murE | spr1373 | spr1384 | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L- lysine Ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. | 0.979 |
murC | murG | spr1373 | spr0604 | UDP-N-acetylmuramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. | Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. | 0.977 |