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psaA protein (Streptococcus pneumoniae R6) - STRING interaction network
"psaA" - Manganese ABC transporter substrate-binding lipoprotein in Streptococcus pneumoniae R6
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Cooccurence
Coexpression
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Textmining
[Homology]
Score
psaAManganese ABC transporter substrate-binding lipoprotein; Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection (By similarity) (309 aa)    
Predicted Functional Partners:
psaC
annotation not available (282 aa)
 
  0.999
psaB
annotation not available (240 aa)
 
  0.997
adcB
annotation not available (278 aa)
   
  0.769
tpx
Thiol peroxidase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Tpx subfamily (172 aa)
         
  0.731
pepO
annotation not available (630 aa)
         
  0.604
spr1480
Metalloregulator (216 aa)
         
  0.573
hgt
annotation not available (180 aa)
           
  0.560
adcC
Zinc transport system ATP-binding protein AdcC; Part of the ATP-driven transport system AdcABC for zinc. Required for transformability (By similarity) (234 aa)
   
  0.558
ply
Pneumolysin; Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity) (471 aa)
           
  0.553
prtA
annotation not available (2144 aa)
           
  0.550
Your Current Organism:
Streptococcus pneumoniae R6
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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