STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nanBSialidase B precursor (neuraminidase B). (697 aa)    
Predicted Functional Partners:
strH
Beta-N-acetyl-hexosaminidase precursor.
 
 
 0.966
nanA
Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.
  
  
0.955
spr1530
Conserved hypothetical protein; Probable Oxidoreductase, GFO/IDH/MOCA family.
 
   
 0.930
aga
Alpha-galactosidase (melibiase).
   
 
 0.912
ply
Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes); Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
      
 0.896
flpA
Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.
      
 0.868
ABC-SBP-9
ABC transporter substrate-binding protein - sugar transport.
 
     0.867
bgaA
Beta-galactosidase precursor.
   
 0.847
lytA
Autolysin (N-acetylmuramoyl-L-alanine amidase).
      
 0.802
hysA
Hyaluronate lyase precursor (hyaluronidase/hyase).
 
  
 0.801
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.