node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
acoL | hk06 | spr1048 | spr1997 | Dihydrolipoamide dehydrogenase. | Histidine kinase. | 0.971 |
acoL | pppL | spr1048 | spr1578 | Dihydrolipoamide dehydrogenase. | Phosphoprotein phosphatase; Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity); Belongs to the PP2C family. | 0.915 |
divIVA | gpsB | spr1505 | spr0332 | Cell-division initiation protein (septum placement); Appears to have a multifaceted role in controlling cell morphology, completion of cell division and separation, as well as chromosome segregation, through a complex interaction web. Seems to be primarily involved in the formation and maturation of the cell poles. | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | 0.909 |
divIVA | mapZ | spr1505 | spr0334 | Cell-division initiation protein (septum placement); Appears to have a multifaceted role in controlling cell morphology, completion of cell division and separation, as well as chromosome segregation, through a complex interaction web. Seems to be primarily involved in the formation and maturation of the cell poles. | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. | 0.955 |
divIVA | pkn2 | spr1505 | spr1577 | Cell-division initiation protein (septum placement); Appears to have a multifaceted role in controlling cell morphology, completion of cell division and separation, as well as chromosome segregation, through a complex interaction web. Seems to be primarily involved in the formation and maturation of the cell poles. | Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...] | 0.971 |
divIVA | pppL | spr1505 | spr1578 | Cell-division initiation protein (septum placement); Appears to have a multifaceted role in controlling cell morphology, completion of cell division and separation, as well as chromosome segregation, through a complex interaction web. Seems to be primarily involved in the formation and maturation of the cell poles. | Phosphoprotein phosphatase; Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity); Belongs to the PP2C family. | 0.843 |
fmt | pkn2 | spr1580 | spr1577 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...] | 0.858 |
fmt | pppL | spr1580 | spr1578 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Phosphoprotein phosphatase; Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity); Belongs to the PP2C family. | 0.919 |
fmt | priA | spr1580 | spr1581 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Primosomal replication factor Y; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. | 0.920 |
fmt | sunL | spr1580 | spr1579 | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | rRNA methylase; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. | 0.994 |
gpsB | divIVA | spr0332 | spr1505 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Cell-division initiation protein (septum placement); Appears to have a multifaceted role in controlling cell morphology, completion of cell division and separation, as well as chromosome segregation, through a complex interaction web. Seems to be primarily involved in the formation and maturation of the cell poles. | 0.909 |
gpsB | mapZ | spr0332 | spr0334 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. | 0.896 |
gpsB | pkn2 | spr0332 | spr1577 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...] | 0.963 |
gpsB | pppL | spr0332 | spr1578 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Phosphoprotein phosphatase; Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity); Belongs to the PP2C family. | 0.730 |
hk06 | acoL | spr1997 | spr1048 | Histidine kinase. | Dihydrolipoamide dehydrogenase. | 0.971 |
hk06 | pkn2 | spr1997 | spr1577 | Histidine kinase. | Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...] | 0.562 |
hk06 | pppL | spr1997 | spr1578 | Histidine kinase. | Phosphoprotein phosphatase; Protein phosphatase able to dephosphorylate StkP-P and other phosphorylated protein substrates. PhpP and its cognate protein kinase StkP appear to constitute a functional signaling couple in vivo, PhpP's primary role being probably to control phosphorylation levels of StkP and of its targets. PhpP thus performs an essential control of StkP activity (By similarity); Belongs to the PP2C family. | 0.665 |
mapZ | divIVA | spr0334 | spr1505 | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. | Cell-division initiation protein (septum placement); Appears to have a multifaceted role in controlling cell morphology, completion of cell division and separation, as well as chromosome segregation, through a complex interaction web. Seems to be primarily involved in the formation and maturation of the cell poles. | 0.955 |
mapZ | gpsB | spr0334 | spr0332 | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | 0.896 |
mapZ | pkn2 | spr0334 | spr1577 | Conserved hypothetical protein; Early cell division protein that marks the future cell division site and supports proper FtsZ ring positioning. | Eukaryotic-type serine/threonine kinase; Protein kinase involved in signal transduction pathways that regulate various cellular processes. Likely senses intracellular peptidoglycan subunits present in the cell division septa of actively growing cells; thus, intracellular unlinked peptidoglycan may serve as the signal molecules that trigger StkP phosphorylation activity on a set of substrates. Plays a crucial role in the regulation of cell shape and cell division of S.pneumoniae through control of at least DivIVA activity. Identified target substrates that are specifically phosphorylate [...] | 0.979 |