Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
ABC-MSP-19ABC transporter membrane-spanning permease - sugar transporter. (302 aa)    
Predicted Functional Partners:
ABC-MSP-18
ABC transporter membrane-spanning permease - sugar transport.
 
 0.998
ABC-SBP-10
ABC transporter substrate-binding protein - sugar transport.
 
 0.995
msmK
ABC transporter ATP-binding protein - multiple sugar transport; Belongs to the ABC transporter superfamily.
 
 
 0.946
malD
ABC transporter membrane-spanning permease - maltose/maltodextrin; Part of the binding-protein-dependent transport system for maltodextrin; probably responsible for the translocation of the substrate across the membrane.
 
 
 0.910
ABC-MSP-14
ABC transporter membrane-spanning permease - sugar transport.
 
 
 0.894
msmG
ABC transporter membrane spanning permease - multiple sugars.
 
 
 0.892
ABC-MSP-16
ABC transporter membrane-spanning permease - sugar transport.
 
 
 0.890
sacA
Sucrose-6-phosphate hydrolase; Belongs to the glycosyl hydrolase 32 family.
  
  
 0.828
ABC-MSP-2
ABC transporter membrane spanning permease - sugar transport.
 
 
 0.826
msmE
ABC transporter substrate-binding protein - multiple sugars.
 
 
 0.784
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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