Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr1622Conserved hypothetical protein; Putative regulator protein. (512 aa)    
Predicted Functional Partners:
spr1626
Hypothetical protein; Belongs to the UPF0337 (CsbD) family.
      
 0.891
spr1623
Hypothetical protein.
      
 0.890
spr1403
Hypothetical protein.
      
 0.882
scpA
Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. Belongs to the ScpA family.
      
 0.829
spr1279
Conserved hypothetical protein; Putative transcription regulator.
      
 0.542
spr0440
Hypothetical protein; Similar to endo-beta-N-acetylglucosaminidase.
  
     0.535
ABC-SBP-11
ABC transporter substrate-binding protein - unknown substrate.
   
  
 0.535
spr0328
Conserved hypothetical protein; Involved in the breakdown of mucin-type O-linked glycans. Specifically removes the T-antigen disaccharide (Gal-beta-1,3-GalNAc- alpha) from extracellular host glycoproteins. Representative of a broadly important class of virulence factors.
  
     0.471
fruA
Fructose specific-phosphotransferase system IIBC component.
  
  
 0.406
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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