Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr1623Hypothetical protein. (190 aa)    
Predicted Functional Partners:
spr1626
Hypothetical protein; Belongs to the UPF0337 (CsbD) family.
     
 0.969
spr1624
Conserved hypothetical protein.
 
   
 0.965
spr1625
Conserved hypothetical protein.
 
   
 0.926
spr1622
Conserved hypothetical protein; Putative regulator protein.
      
 0.890
spr1404
Conserved hypothetical protein; Putative Mga-like regulatory protein.
      
 0.744
iga
Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region.
  
     0.709
zmpB
Zinc metalloprotease; Similar to IgA1 protease.
  
     0.703
spr0255
Conserved hypothetical protein.
 
     0.694
spr0927
Conserved hypothetical protein.
  
     0.657
era
GTPase/GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity). Complements an E.coli era disruption mutant. Binds 16S rRNA as well as poly(U) RNA, binding to the latter is inhibited by liposomes; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.
      
 0.654
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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