Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ccpACatabolite control protein. (333 aa)    
Predicted Functional Partners:
codY
Transcriptional pleiotropic repressor; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family.
    
 
 0.939
rgg
Positive transcriptional regulator of glucosyltransferase and Spp phenotype.
      
 0.739
spr1301
Conserved hypothetical protein; Probable transcription regulator, GntR family.
  
   
 0.703
hprK
HPr(ser-P)kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable ca [...]
      
 0.692
ptsH
Histidine-containing phosphocarrier protein of the PTS.
   
 
 0.659
glnR
Transcriptional repressor of the glutamine synthetase gene.
      
 0.628
spr1832
Conserved hypothetical protein; Putative transcription regulator.
  
   
 0.627
purR
Activator of purine biosynthetic genes; Controls the transcription of the pur operon for purine biosynthetic genes.
      
 0.613
adcR
Transcriptional repressor for Zn(2+)-responsive expression.
   
  
 0.601
argR
Arginine repressor; Regulates arginine biosynthesis genes.
      
 0.600
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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