Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mgtCMg(2+) transport ATPase/permease. (236 aa)    
Predicted Functional Partners:
phoP
Response regulator.
   
 
 0.898
ABC-MSP-20
ABC transporter membrane-spanning permease - unknown substrate.
       0.784
ABC-NBD-26
ABC transporter ATP-binding protein - unknown substrate; Belongs to the ABC transporter superfamily.
       0.772
ABC-NBD-2
ABC transporter ATP-binding protein - unknown substrate; Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system.
      
 0.742
trmD
tRNA (guanine-N1)-methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family.
     
 0.615
spr1475
Hypothetical protein.
  
  
 0.600
ABC-SBP-11
ABC transporter substrate-binding protein - unknown substrate.
       0.539
spr1640
Hypothetical protein.
       0.533
ftsH
Cell-division protein / general stress protein (class III heat-shock); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family.
    
 
 0.532
pacL
P-type ATPase - calcium transporter; Putative calcium transporter.
  
 
 0.496
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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