pfbA protein (Streptococcus pneumoniae) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

pfbA

Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood. (719 aa)

Predicted Functional Partners:

flpA

0.884

pepO

0.881

spr1966

0.798

spr1498

0.790

spr1651

0.773

hysA

0.743

bgaA

0.738

spr1954

0.683

nadC

0.615

nanA

0.607

Your Current Organism:

Streptococcus pneumoniae

NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bgaA	flpA	spr0565	spr0868	Beta-galactosidase precursor.	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	0.558
bgaA	hysA	spr0565	spr0286	Beta-galactosidase precursor.	Hyaluronate lyase precursor (hyaluronidase/hyase).	0.734
bgaA	nanA	spr0565	spr1536	Beta-galactosidase precursor.	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.	0.992
bgaA	pfbA	spr0565	spr1652	Beta-galactosidase precursor.	Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.	0.738
bgaA	spr1498	spr0565	spr1498	Beta-galactosidase precursor.	Conserved hypothetical protein; Putative large secreted protein.	0.781
bgaA	spr1954	spr0565	spr1954	Beta-galactosidase precursor.	Hypothetical protein.	0.749
bgaA	spr1966	spr0565	spr1966	Beta-galactosidase precursor.	Conserved hypothetical protein.	0.774
flpA	bgaA	spr0868	spr0565	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	Beta-galactosidase precursor.	0.558
flpA	hysA	spr0868	spr0286	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	Hyaluronate lyase precursor (hyaluronidase/hyase).	0.673
flpA	nanA	spr0868	spr1536	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.	0.916
flpA	pepO	spr0868	spr1491	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	Endopeptidase O.	0.603
flpA	pfbA	spr0868	spr1652	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.	0.884
hysA	bgaA	spr0286	spr0565	Hyaluronate lyase precursor (hyaluronidase/hyase).	Beta-galactosidase precursor.	0.734
hysA	flpA	spr0286	spr0868	Hyaluronate lyase precursor (hyaluronidase/hyase).	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	0.673
hysA	nanA	spr0286	spr1536	Hyaluronate lyase precursor (hyaluronidase/hyase).	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.	0.896
hysA	pfbA	spr0286	spr1652	Hyaluronate lyase precursor (hyaluronidase/hyase).	Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.	0.743
nadC	pfbA	spr1829	spr1652	Probable nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.	Hypothetical protein; Acts as a fibronectin-dependent adhesin and invasin. Binds host (in this case human) fibronectin, plasmin, plasminogen, and human serum albumin. Where the bacteria adhere to human cells there is major recruitment of microvilli which seem to fuse to cover the streptococcal chains. Antibodies to this protein reduce bacterial growth in human blood.	0.615
nanA	bgaA	spr1536	spr0565	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.	Beta-galactosidase precursor.	0.992
nanA	flpA	spr1536	spr0868	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.	Fibronectin-binding protein-like protein A; Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits.	0.916
nanA	hysA	spr1536	spr0286	Sialidase A precursor (neuraminidase A); Belongs to the glycosyl hydrolase 33 family.	Hyaluronate lyase precursor (hyaluronidase/hyase).	0.896

page 1 of 3

Server load: low (10%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Databases

Co-occurrence

Textmining

Co-expression

© STRING Consortium 2026

Credits

Access

Info

About