Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
spr1654Conserved hypothetical protein; Putative role in biosynthesis of amino sugar; Belongs to the DegT/DnrJ/EryC1 family. (417 aa)    
Predicted Functional Partners:
capD
CapD protein, required for the biosynthesis of type 1 capsular polysaccharide.
 
 
 0.999
spr1655
Conserved hypothetical protein; Putative glycosyltransferase.
 
 0.999
spr0136
Glycosyl transferase, family 2.
  
  
 0.906
rffD
UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase; Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.
 
  
 0.843
spr0091
Conserved hypothetical protein; Putative sugar transferase related protein.
 
   
 0.789
spr1224
Conserved hypothetical protein; Similar to capsular polysaccharide biosynthsis protein.
 
  
 0.767
epsG
Glycosyltransferase involved exopolysaccharide (EPS) synthesis.
 
  
 0.736
spr0965
Hypothetical protein.
 
  
 0.657
spr1150
Conserved hypothetical protein; Probable oligosaccharide repeat unit transporter.
 
  
 0.657
cps2L
The type 2 capsule locus of Streptococcus pneumoniae; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family.
  
  
 0.636
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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