Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
dpnDRestriction system of S. pneumoniae. (153 aa)    
Predicted Functional Partners:
dpnC
Type II restriction enzyme DpnI (dpnC); Recognizes the double-stranded and methylated sequence G(Me)ATC and cleaves after A-2.
  
  
 0.983
spr1130
Hypothetical protein; Probable endonuclease.
      
 0.736
spr1666
Conserved hypothetical protein; Similar to E. coli PaaI protein involved in phenylacetic acid degradation.
       0.456
comC
Competence stimulating peptide precursor (CSP); Acts as a pheromone, induces cells to develop competence for genetic transformation; Belongs to the ComC family.
      
 0.402
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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