Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
spr1666Conserved hypothetical protein; Similar to E. coli PaaI protein involved in phenylacetic acid degradation. (141 aa)    
Predicted Functional Partners:
galK
Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.
  
    0.678
galT-2
Galactose-1-phosphate uridylyltransferase.
       0.648
plsX
Involved in fatty acid/phospholipid synthesis; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. It is active with both saturated and unsaturated acyl-ACP.
  
  
 0.570
phaB
Enoyl-CoA hydratase II; Catalyzes the isomerization of trans-2-decenoyl-ACP to cis-3- decenoyl-ACP. Most active with 10-carbon enoyl-ACP. Can also use 12- carbon enoyl-ACP as substrate, but not 14- and 16-carbon enoyl-ACP. Belongs to the enoyl-CoA hydratase/isomerase family.
 
 
 0.472
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
  
 0.469
dpnD
Restriction system of S. pneumoniae.
       0.456
dpnC
Type II restriction enzyme DpnI (dpnC); Recognizes the double-stranded and methylated sequence G(Me)ATC and cleaves after A-2.
       0.456
galR
GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon.
     
 0.452
def
Formylmethionine deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins; Belongs to the polypeptide deformylase family.
     
 0.437
cca
tRNA nucleotidyltransferase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.
  
   0.401
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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