Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
proWXABC transporter membrane-spanning permease - choline transporter. (506 aa)    
Predicted Functional Partners:
proV
ABC transporter ATP-binding protein - choline transporter.
 
 0.999
marR-2
Transcriptional regulator - MarR family.
  
  
 0.891
spr1680
Hypothetical protein; Putative transcriptional regulator.
  
    0.888
gidA-2
Glucose inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily.
   
  
 0.868
spr1679
Hypothetical protein.
       0.833
adhE
Alcohol-acetaldehyde dehydrogenase; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
  
  
 0.539
glnH
ABC transporter substrate binding protein - glutamine transport.
     
 0.516
glnP-6
ABC transporter membrane spanning permease - glutamine transport.
     
 0.516
nusA
Transcription termination; Participates in both transcription termination and antitermination.
     
 0.505
xylR
Xylose repressor protein.
  
    0.500
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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