Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
trePPhosphotransferase system, trehalose-specific IIBC component. (705 aa)    
Predicted Functional Partners:
ptsG
PTS glucose-specific enzyme IIABC component.
 
 
0.985
PTS-EII-12
Phosphotransferase system sugar-specific EII component.
 
 
0.982
scrA
Phosphotransferase system enzyme II.
 
 
0.981
dexS
Dextran glucosidase; Also highly similar to trehalose-6-phosphate hydrolase.
 
 
 0.981
ptsH
Histidine-containing phosphocarrier protein of the PTS.
  
 0.980
fruA
Fructose specific-phosphotransferase system IIBC component.
 
  
 0.978
strH
Beta-N-acetyl-hexosaminidase precursor.
  
  
 0.949
spr1949
Hypothetical protein.
  
  
 0.942
spr0422
Hypothetical protein.
  
  
 0.931
PTS-EII-15
Phosphotransferase system sugar-specific EII component.
 
 0.930
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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