Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ABC-NBD-29ABC transporter ATP binding protein - unknown substrate. (294 aa)    
Predicted Functional Partners:
spr1816
Conserved hypothetical protein.
 
  
 0.980
hk11
Histidine kinase.
 
   
 0.911
rr11
Response regulator.
  
 0.865
spr1818
Hypothetical protein.
       0.644
zmpB
Zinc metalloprotease; Similar to IgA1 protease.
  
    0.539
iga
Immunoglobulin A1 protease; Zinc metalloproteinase which cleaves human immunoglobulin A1 (IgA1) in the hinge region.
  
     0.536
ABC-NP
ABC transporter ATP-binding/membrane spanning permease - possible multidrug resistance.
  
  0.531
licC
Homologous to LicC, which regulates expression of LPS epitopes in H. influenzae.
  
     0.501
spr0860
Hypothetical protein.
  
 
 0.478
ABC-NBD-3
ABC transporter ATP-binding protein - iron transport; Belongs to the ABC transporter superfamily.
 
    
0.467
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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