node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dacA | pbp1b | spr0776 | spr1909 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Penicillin-binding protein 1b. | 0.941 |
dacA | pbp2a | spr0776 | spr1823 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Penicillin-binding protein 2a. | 0.915 |
dacA | pbp2b | spr0776 | spr1517 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Penicillin-binding protein 2B. | 0.940 |
dacA | pbpA | spr0776 | spr0329 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Penicillin-binding protein 1A; Cell wall formation; In the C-terminal section; belongs to the transpeptidase family. | 0.918 |
dacA | pbpX | spr0776 | spr0304 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. | 0.930 |
dacA | spr0554 | spr0776 | spr0554 | D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family. | Conserved hypothetical protein; Putative carboxypeptidase. | 0.917 |
ftsW | gpsB | spr0973 | spr0332 | Cell division protein FtsW; Belongs to the SEDS family. | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | 0.640 |
ftsW | pbp1b | spr0973 | spr1909 | Cell division protein FtsW; Belongs to the SEDS family. | Penicillin-binding protein 1b. | 0.930 |
ftsW | pbp2a | spr0973 | spr1823 | Cell division protein FtsW; Belongs to the SEDS family. | Penicillin-binding protein 2a. | 0.923 |
ftsW | pbp2b | spr0973 | spr1517 | Cell division protein FtsW; Belongs to the SEDS family. | Penicillin-binding protein 2B. | 0.982 |
ftsW | pbpA | spr0973 | spr0329 | Cell division protein FtsW; Belongs to the SEDS family. | Penicillin-binding protein 1A; Cell wall formation; In the C-terminal section; belongs to the transpeptidase family. | 0.815 |
ftsW | pbpX | spr0973 | spr0304 | Cell division protein FtsW; Belongs to the SEDS family. | Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. | 0.997 |
ftsW | rodA | spr0973 | spr0712 | Cell division protein FtsW; Belongs to the SEDS family. | Rod shape determining protein; Belongs to the SEDS family. | 0.579 |
gpsB | ftsW | spr0332 | spr0973 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Cell division protein FtsW; Belongs to the SEDS family. | 0.640 |
gpsB | mecA | spr0332 | spr1220 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Negative regulator of genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis. | 0.571 |
gpsB | pbp1b | spr0332 | spr1909 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Penicillin-binding protein 1b. | 0.580 |
gpsB | pbp2a | spr0332 | spr1823 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Penicillin-binding protein 2a. | 0.992 |
gpsB | pbp2b | spr0332 | spr1517 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Penicillin-binding protein 2B. | 0.923 |
gpsB | pbpA | spr0332 | spr0329 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Penicillin-binding protein 1A; Cell wall formation; In the C-terminal section; belongs to the transpeptidase family. | 0.950 |
gpsB | pbpX | spr0332 | spr0304 | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. | Penicillin-binding protein 2X; Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins. | 0.849 |