Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
spr1850Hypothetical protein. (207 aa)    
Predicted Functional Partners:
spr1851
Hypothetical protein.
       0.747
yidC2
Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
       0.724
rnpA
Ribonuclease P - protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
       0.724
PTS-EII-18
Phosphotransferase system sugar-specific EII component.
       0.614
PTS-EII-17
Phosphotransferase system sugar-specific EII component.
       0.568
PTS-EII-16
Phosphotransferase system sugar-specific EII component.
       0.422
araD
L-ribulose 5-phosphate 4-epimerase.
       0.410
sga
Hexulose-6-phosphate isomerase.
       0.410
sgh
Hexulose-6-phosphate synthase (HumpS).
       0.410
serA
Phosphoglycerate dehydrogenase; GTPase that plays an essential role in the late steps of ribosome biogenesis.
  
    0.408
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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