Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
spr1965Hypothetical protein. (1038 aa)    
Predicted Functional Partners:
fcsR
Regulator of fucose operon.
     
 0.914
fucU
Fucose pathway protein, function unknown; Belongs to the RbsD / FucU family.
 
  
 0.888
spr1966
Conserved hypothetical protein.
 
    0.801
fucA
L-fuculose phosphate aldolase.
  
  
 0.790
fucI
L-fucose isomerase; Converts the aldose L-fucose into the corresponding ketose L- fuculose.
  
    0.641
PTS-EII-20
Phosphotransferase system sugar-specific EII component.
  
    0.612
ftsK
Cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region (By similarity). Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination; Belongs to the FtsK/SpoIIIE/SftA family.
   
 
 0.607
PTS-EII-19
Phosphotransferase system sugar-specific EII component.
  
    0.600
fcsK
Fucose kinase.
 
    0.562
mip
Macrophage infectivity potentiator protein; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. Belongs to the AhpD family.
  
   
 0.557
Your Current Organism:
Streptococcus pneumoniae
NCBI taxonomy Id: 171101
Other names: S. pneumoniae R6, Streptococcus pneumoniae (strain ATCC BAA-255 / R6), Streptococcus pneumoniae R6, Streptococcus pneumoniae str. R6
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